The Samuel Crane House was built by Samuel Crane, a prominent Prescott business man and head of the largest board and barge forwarding house in Canada. Mr. Crane represented the County of Grenville in parliament and was called to the Legislative Council in 1848, and became The Honorable Samuel Crane. 

The Samuel Crane House was later used as a doctor's office and in 1905 sold to the Roman Catholic Episcopal Corporation of the Diocese of Kingston for use as a convent. 

This house is an imposing structure and appears to be a mix of Upper Canada Neo Classic style and Upper Canada Regency. The home is comprised of two sections. The front and main part of the home was built around 1830 with the smaller section at the rear built around 1875.

The windows are double hung with elongated sash and thin glazing bars. There are twelve sections to each window. The lintels over the doors and windows are stone. The exterior of the home is stucco over stone. There is a hip roof gently sloping down to the eaves. The eaves is the most prominent part of the home. It is supported by forty-four wood carved ornamental brackets which give strength and beauty to the entire roof line. 

This beautiful home sits in the centre of a large lot immediately east of the Roman Catholic Church. It is a stately and imposing structure which the builder, The Honorable Samuel Crane, a man of distinction, no doubt intended it to be.